The Mitte Museum emerged in 2004 out of a merger of the former Mitte Museum, Heimatmuseum Tiergarten and Heimatmuseum Wedding. The consolidation took place in response to Berlin's own district and administrative reform at the time. The Mitte Museum is located in the oldest remaining schoolhouse in Wedding dating back to the 1860s. The exhibition also includes an original preserved classroom. The history of the district is told in a total of 14 rooms with a focus on the 19th and 20th centuries.
The museum's "Land und Leute" ("Land and People") section explores the founding of the double-city of Cölln and Berlin, the colonization of Wedding and Moabit and the Tiergarten park complex. The history of immigrants is also told – all the way from the Huguenots and the country folk who streamed into the city in the 19th century to today's migrants. The "Geist, Glanz und Gewerbe" ("Mind, Splendour and Business") section gives an overview of the manufacturing and industrialisation eras – using German businessman August Borsig as one example among others – and the emergence of heavy industry. The salon culture of the early 19th century and the birth of variety shows, cinema and radio are also examined.
The museum features a large archive and a regional history reference library. Guided tours, workshops and project days for children and young adults are offered on a regular basis.
Closed from 1 April 2016 until Autumn 2019 due to reconstruction work.